Liver Transplantation and Liver Surgery
We have compiled a list of frequently asked questions by those involved in liver transplants & surgery, Whether from transplant recipients, donors or families. If you do not find an answer to your question below, please email us
your query regarding liver transplantation. We will answer your query within 72 hours.
Liver Frequenty Asked Questions:
Who needs a liver transplant?
Anyone with a long-standing (chronic) or sudden onset (acute) severe
liver disease leading to liver failure needs to be considered for
a liver transplant.
The common diseases requiring transplant are advanced liver disease
due to Hepatitis C, Hepatitis B, or alcohol induced damage. The
other diseases for which this is done are biliary problems like
primary sclerosing cholangitis, primary biliary cirrhosis and biliary
atresia (children), metabolic diseases, and primary liver cancer.
What are the symptoms of liver disease?
Mild or moderate liver disease may cause no symptoms at all.
Severe liver disease causes water retention (swollen ankles, water
in the abdomen or ascites), loss of energy and weakness, jaundice,
blood vomiting or black stools, drowsiness, confusion or some behavioural
changes, and repeated infections especially in the abdominal fluid
The common abnormalities in the blood tests are low blood counts
(Hb, TLC, platelets), prolonged prothrombin time, low serum albumin
and increased serum bilirubin. In advanced stages, serum sodium
and creatinine are also affected.
What is the procedure for proceeding with liver transplant?
You should seek an appointment with Dr Soin who will assess the
need for a transplant, your fitness for it and counsel you regarding
all aspects of the procedure.
If a transplant is thought suitable, you will then need a suitable
donor from the family. The other option is to wait for a cadaveric
organ (organs donated voluntarily by families of brain dead patients
before artificial life support is withdrawn) but that wait can be
very long since the cadaveric organ donation rates in India are
Who can be a liver donor?
For living donation, the person must be a close relative aged between
18-55 years, have a matching blood group, and weigh between 50-90kg
(but not fat).
Is liver donation safe?
Liver donation is very safe since the liver has great reserve and
regenerates to its original size quickly (within 2-3 months) after
a part of it is removed. The donor suffers from no long-term effects,
does not have to take any medication beyond 2-3 weeks, and is back
to normalcy in a month. He/she can resume strenuous physical activity
(weight lifting etc) in 3 months.
What is the success rate of liver transplantation?
The success of the transplant procedure depends on the expertise
available at a given centre. In most well established centres across
the world including Dr. Soin's Unit at Sir Ganga Ram Hospital, Delhi,
when a liver transplant is performed before the patient becomes
too ill with liver disease, it is successful in more than 90% patients
and gives an excellent quality of life with a normal life expectancy
Are life-long medicines necessary after liver transplant?
Yes, but the number of medicines and the doses decrease with passage
of time. Most patients are only on small doses of 1 or 2 medicines
at about a year after transplant, and down to a single medicine
in 2-4 years which needs to be taken life-long.
After a liver transplant, does a person have high infection rates
and lead a very restricted life?
This is not true. Although such persons do have a higher susceptibility
to infection than usual, this rapidly diminishes by 3-6 months after
transplant when the doses of the immunosuppressive medicine are
reduced. So they have to be a little cautious initially, but later,
even though the infection rate remains a little higher, this does
not interfere with normal daily activities. The infections that
do occur can be treated easily in most cases.